Redesigning the Sequence Logo with Glyph-based Approaches to Aid Interpretation

dc.contributor.authorMaguire, Eamonnen_US
dc.contributor.authorRocca-Serra, Philippeen_US
dc.contributor.authorSansone, Susanna-Assuntaen_US
dc.contributor.authorChen, Minen_US
dc.contributor.editorN. Elmqvist and M. Hlawitschka and J. Kennedyen_US
dc.date.accessioned2014-12-16T07:21:06Z
dc.date.available2014-12-16T07:21:06Z
dc.date.issued2014en_US
dc.description.abstractSequence logos have been a prominent visualization tool in biological research since their inception two decadesago. Their primary use is in communicating conservation of biological sequences (protein, DNA or RNA), toindicate largest conservation at particular positions - namely places where only ever one or two possible residues(nucleotides or amino acids) are observed. Conservation is indicative of functional importance, as changes, beingselected against, reveal a loss of fitness for living organism or cells. Criticism of the sequence logo has longexisted, largely directed towards perception problems caused through use of letter height to indicate frequency.Here, we present a solution for use as a static image in publications or interactively on the web to address thereported flaws of the sequence logo. In addition to our improvements, we propose glyph based enhancements, tohighlight qualitatively relevant chemical insights resulting from residue substitution between sequencesen_US
dc.description.seriesinformationEuroVis - Short Papersen_US
dc.identifier.isbn978-3-905674-69-9en_US
dc.identifier.urihttps://doi.org/10.2312/eurovisshort.20141159en_US
dc.publisherThe Eurographics Associationen_US
dc.titleRedesigning the Sequence Logo with Glyph-based Approaches to Aid Interpretationen_US
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