Pathway Preserving Representation of Metabolic Networks
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Date
2011
Journal Title
Journal ISSN
Volume Title
Publisher
The Eurographics Association and Blackwell Publishing Ltd.
Abstract
Improvements in biological data acquisition and genomes sequencing now allow to reconstruct entire metabolic networks of many living organisms. The size and complexity of these networks prohibit manual drawing and thereby urge the need of dedicated visualization techniques. An efficient representation of such a network should preserve the topological information of metabolic pathways while respecting biological drawing conventions. These constraints complicate the automatic generation of such visualization as it raises graph drawing issues. In this paper we propose a method to lay out the entire metabolic network while preserving the pathway information as much as possible. That method is flexible as it enables the user to define whether or not node duplication should be performed, to preserve or not the network topology. Our technique combines partitioning, node placement and edge bundling to provide a pseudo-orthogonal visualization of the metabolic network. To ease pathway information retrieval, we also provide complementary interaction tools that emphasize relevant pathways in the entire metabolic context.
Description
@article{:10.1111/j.1467-8659.2011.01951.x,
journal = {Computer Graphics Forum},
title = {{Pathway Preserving Representation of Metabolic Networks}},
author = {Lambert, Antoine and Dubois, J. and Bourqui, Romain},
year = {2011},
publisher = {The Eurographics Association and Blackwell Publishing Ltd.},
ISSN = {1467-8659},
DOI = {/10.1111/j.1467-8659.2011.01951.x}
}